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Laser photoradiation therapy of cancer following hematoporphyrin sensitization
Author(s) -
Wile Alan G.,
Dahlman Anton,
Burns Robert G.,
Berns Michael W.
Publication year - 1982
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1900020206
Subject(s) - hematoporphyrin , medicine , photodynamic therapy , malignancy , cancer , radiation therapy , squamous cell cancer , basal cell , pathology , chemistry , organic chemistry
Hematoporphyrin derivative‐photoradiation therapy (HPD‐PRT) of human malignancy has been performed on 267 tumor sites in 50 patients. Tumor response has been assayed at 24 hours and one month following treatment with 625–635 nm light from an argon laser‐pumped dye laser. The majority of tumors treated were dermal breast cancer recurrences (21 cases), local recurrence of ENT squamous cell carcinomas (16 cases), and ENT cutaneous metastases of squamous cell carcinomas (9 cases). A 30‐day favorable response was judged to be either complete regression of the tumor or reduction of tumor diameter by greater than 50%. The above categories of tumors had a combined favorable response of 81%. Appropriate dosimetry is discussed.