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Carbon dioxide laser therapy of cervical intraepithelial neoplasia: Factors determining success rate
Author(s) -
Burke Louis,
Covell Linda,
Antonioli Donald
Publication year - 1980
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1900010202
Subject(s) - carbon dioxide laser , lesion , medicine , cervical intraepithelial neoplasia , biopsy , persistence (discontinuity) , surgery , coagulative necrosis , laser therapy , laser , radiology , pathology , laser surgery , cervical cancer , optics , cancer , physics , geotechnical engineering , engineering
Sixty patients with biopsy proven CIN were treated with CO 2 laser. Severity of the lesion was equally divided among all three grades of CIN. All patients were biopsied immediately after laser therapy and at six and twelve weeks past treatment. Persistence or absence of disease was evaluated with respect to severity of disease, size of lesion, method of applying laser, whether the endocervical canal was involved, whether only the lesion or the entire transformation zone was lasered, and depth of laser effect. The persistence of disease was 36.7 percent after therapy. Success was not related to severity of disease, size of lesion, or whether the endocervical canal was involved. It was related to depth of coagulation necrosis, method of applying the laser beam, and if the entire transformation zone was treated.