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Extended theory of selective photothermolysis
Author(s) -
Altshuler G.B.,
Anderson R.R.,
Manstein D.,
Zenzie H.H.,
Smirnov M.Z.
Publication year - 2001
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1136
Subject(s) - fluence , diffusion , diffusion theory , thermal , range (aeronautics) , laser , constant (computer programming) , materials science , relaxation (psychology) , planar , optics , molecular physics , chemistry , physics , computer science , thermodynamics , composite material , biology , computer graphics (images) , neuroscience , programming language
Background and Objective We present a new theory of selective thermal damage of non‐uniformly pigmented structures in biological tissues. Spatial separation of the heavily pigmented areas and the target requires limitation of the pigment temperature and heat diffusion from the pigmented to the targeted areas. Study Design/Materials and Methods A concept of selective target damage by heat diffusion is presented for three target geometries: planar, cylindrical, and spherical. An in vitro experiment is described in which the dependence of thermal damage on pulsewidth at constant fluence was evaluated. Results The in vitro experiment showed that the size of the damage zone for similar hair follicles was pulsewidth‐independent over a very broad range of pulsewidths (30–400 ms). We formulated a new theory (extended theory of photothermolysis) to interpret the experimental results. Conclusions Based on this new theory, the treatment pulsewidth for non‐uniformly pigmented targets is significantly longer than the target thermal relaxation time (TRT). The theory provides new recommendations for photoepilation and photosclerotherapy parameters. Lasers Surg. Med. 29:416–432, 2001. © 2001 Wiley‐Liss, Inc.