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In vivo laser‐induced interstitial thermotherapy of pig liver with a temperature‐controlled diode laser and MRI correlation
Author(s) -
Wohlgemuth Walter A.,
Wamser Günther,
Reiss Thomas,
Wagner Theodor,
Bohndorf Klaus
Publication year - 2001
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1131
Subject(s) - in vivo , laser , medicine , nuclear medicine , necrosis , lesion , magnetic resonance imaging , pathology , liver tissue , biomedical engineering , radiology , biology , optics , physics , microbiology and biotechnology
Background and Objective To evaluate the efficacy of a new temperature‐controlled Diode laser to generate in vivo tissue coagulations with laser‐induced interstitial thermotherapy (LITT) in pig liver and MRI‐correlation of these necroses. Study Design/Materials and Methods Each of four animal subjects received eight treatments at four different constant temperatures (70, 80, 90, and 100°C) and at two out of three different intervals (3, 6, 9 minutes), resulting in a total of 32 lesions. After sacrificing, the liver was examined in an open MRI (0.35T). Tissue necrosis was measured macroscopically and compared with the size measured by MRI. Results The size of the necrosis was energy dependent with the largest extent at 100°C at 9 minutes (2.1 cm). The correlation between macroscopic lesion size and MRI findings was significant ( P > 0.036). Histological workup excluded carbonization in every case. Conclusions LITT carried out with the Diode laser provides reproducible necroses of pig liver in vivo. MR‐imaging results compared favorably with those obtained by pathologic specimens. Lasers Surg. Med. 29:374–378, 2001. © 2001 Wiley‐Liss, Inc.