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Use of a new ICG‐Dye‐enhanced diode laser for percutaneous laser disc decompression
Author(s) -
Sato Masato,
Ishihara Miya,
Arai Tsunenori,
Asazuma Takashi,
Kikuchi Toshiyuki,
Hayashi Takuya,
Yamada Takahiro,
Kikuchi Makoto,
Fujikawa Kyosuke
Publication year - 2001
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1120
Subject(s) - laser , indocyanine green , irradiation , biomedical engineering , diode , materials science , chemistry , nuclear medicine , optics , surgery , optoelectronics , medicine , physics , nuclear physics
Background and Objective The lasers used today for Percutaneous Laser Disc Decompression (PLDD) can not selectively ablate the nucleus pulposus (NP). We hypothesized that if indocyanine green dye were injected into the NP, 805 nm diode laser irradiation would result in selective and safe removal of NP tissue without damaging nearby tissues. Study Design/Materials and Methods Twelve beagle dogs were used for three experiments, i.e., determination of attenuation coefficients of NP and AF, determination of weight of NP before and after laser irradiation, and histopathological study. Results The attenuation coefficient at 805 nm of NP which had been homogenized in the presence of ICG was 2521.3/cm. Upon application of the diode laser at a power of 1, 3, or 5 W (the intensity of laser irradiation: 0.353, 1.061, or 1.768 × 10 3 W/cm 2 ) to NPs into which ICG had been injected, the weight of the NPs decreased by a mean 20, 45, and 65%, respectively. Macroscopic and microscopic examination of the discs after PLDD showed that only the NP where the tissues were stained by ICG were removed. Conclusions These results indicated that the combined use of ICG and diode laser irradiation effectively and selectively ablates the NP with low laser power. Lasers Surg. Med. 29:282–287, 2001. © 2001 Wiley‐Liss, Inc.