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Permeabilization and recovery of the stratum corneum in vivo: The synergy of photomechanical waves and sodium lauryl sulfate
Author(s) -
Lee Shun,
McAuliffe Daniel J.,
Kollias Nikiforos,
Flotte Thomas J.,
Doukas Apostolos G.
Publication year - 2001
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1101
Subject(s) - stratum corneum , transdermal , chemistry , biophysics , pulmonary surfactant , sodium dodecyl sulfate , sodium , sodium sulfate , in vivo , chromatography , dermis , biochemistry , organic chemistry , pharmacology , anatomy , pathology , medicine , microbiology and biotechnology , biology
Background and Objective: Photomechanical waves render the stratum corneum permeable and allow macromolecules to diffuse into the epidermis and dermis. The aim of this study was to investigate the combined action of photomechanical waves and sodium lauryl sulfate, an anionic surfactant, for transdermal delivery. Study Design/Materials and Methods: A single photomechanical wave was applied to the skin of rats in the presence of sodium lauryl sulfate. The sodium lauryl sulfate solution was removed and aqueous solutions of rhodamine‐B dextran (40 kDa molecular weight) were applied to the skin at time points 2, 30, and 60 minutes post‐exposure. The presence of rhodamine‐B dextran in the skin was measured by fluorescence emission spectroscopy in vivo and fluorescence microscopy of frozen biopsies. Results: The use of sodium lauryl sulfate delayed the recovery of the stratum corneum barrier and extended the time available for the diffusion of dextran through it. Conclusion: The combination of photomechanical waves and surfactants can enhance transdermal drug delivery. Lasers Surg. Med. 29:145–150, 2001. © 2001 Wiley‐Liss, Inc.