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Laser enhancement in hepatic regeneration for partially hepatectomized rats
Author(s) -
de Castroe Silva O.,
Zucoloto S.,
Menegazzo L.A.G.,
Granato R.G.,
Marcassa L.G.,
Bagnato V.S.
Publication year - 2001
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1089
Subject(s) - regeneration (biology) , hepatectomy , stimulation , laser , liver regeneration , chemistry , medicine , biology , microbiology and biotechnology , surgery , optics , physics , resection
Background and Objective The bio‐stimulation effect of laser has been observed in many areas of Medicine. However, there are a few works which investigate its use for liver regeneration. Most of their results were inconclusive due to the use of high power lasers . This work was carried out to investigate the bio‐stimulation effect of laser in liver regeneration using low power lasers. Study Design/Materials and Methods We used Wistar male rats, which were irradiated with laser light (wavelength 590 nm and intensity of 50 mW/cm 2 ) for 5 minutes after 70% hepatectomy. The respiratory mitochondrial activity, the serum level of aminotransferase and the PCNA were measured. Results Our results show a dramatic increase in the mitochondrial activity for the laser treated group at 24 hours after the hepatectomy. Conclusions We conclude that the laser promotes a bio‐stimulation effect on the early stages of liver regeneration without any detectable damage of the cells. Lasers Surg. Med. 29:73–77, 2001. © 2001 Wiley‐Liss, Inc.