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Attenuation of infarct size in rats and dogs after myocardial infarction by low‐energy laser irradiation
Author(s) -
Oron Uri,
Yaakobi Tali,
Oron Amir,
Hayam Gal,
Gepstein Lior,
Rubin Ofer,
Wolf Tamir,
Haim Shlomo Ben
Publication year - 2001
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.1039
Subject(s) - irradiation , myocardial infarction , laser , medicine , infarction , cardiology , artery , occlusion , nuclear medicine , optics , physics , nuclear physics
Background and Objective The aim of the present study was to investigate the possibility that low‐energy laser irradiation attenuates infarct size formation after induction of chronic myocardial infarction (MI) in small and large experimental animals. Study Design/Materials and Methods Laser irradiation was applied to the infarcted area of rats and dogs at various power densities (2.5 to 20 mW/cm 2 ) after occlusion of the coronary artery. Results In infarcted laser‐irradiated rats that received laser irradiation immediately and 3 days after MI at energy densities of 2.5, 6, and 20 mW/cm 2 , there was a 14%, 62% (significant; P < 0.05), and 2.8% reduction of infarct size (14 days after MI) relative to non–laser‐irradiated rats, respectively. In dogs, a 49% (significant; P < 0.01) reduction of infarct size was achieved. Conclusion The results of the present study indicate that delivery of low‐energy laser irradiation to infarcted myocardium in rats and dogs has a profound effect on the infarct size after MI. Lasers Surg. Med. 28:204–211, 2001. © 2001 Wiley‐Liss, Inc.