Premium
Arterial wall strength after endovascular photodynamic therapy
Author(s) -
Gabeler Edward E.E.,
van Hillegersberg Richard,
Sluiter Wim,
Kliffen Mike,
Statius van Eps Randolph G.,
Honkoop Jan,
Carlier Stephane G.,
van Urk Hero
Publication year - 2003
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.10187
Subject(s) - photodynamic therapy , medicine , bursting , intimal hyperplasia , diffuser (optics) , urology , bar (unit) , nuclear medicine , surgery , chemistry , smooth muscle , biology , light source , optics , physics , organic chemistry , neuroscience , meteorology
Abstract Background and Objectives Vascular photodynamic therapy (PDT) inhibits intimal hyperplasia (IH) induced by angioplasty in rat iliac arteries by eradicating the proliferating smooth muscle cells. This process may jeopardise the structure and strength of the arterial wall, reflected by a decreased bursting pressure. Study design/Materials and Methods Thirty male Wistar rats of 250–300 g were subdivided into 3 groups (n = 10). In all groups, IH was induced by balloon injury (BI). One experimental group received PDT at 50 J/cm diffuser length, the other group at 100 J/cm diffuser length. The third group served as control group and received no PDT. In half of each group the bursting pressure was analyzed after 2 hours (n = 5), in the other half after 1 year. Results Two hours after the procedure the bursting pressure was 3.37 ± 0.58 (±SEM) bar in the BI + PDT 50 and 3.96 ± 0.43 bar in the BI + PDT 100 group, compared to 2.20 ± 0.27 bar in the BI group ( P < 0.05). After 1 year these values were 3.18 ± 0.87 bar in the BI + PDT 50 ( P < 0.05) and 2.02 ± 0.31 bar in the BI + PDT 100 group, compared to 2.10 ± 0.30 bar in the BI group (NS). In the BI + PDT 100 group, 3 out of 5 rats appeared to have aneurysmal dilatation after 1 year. Conclusions Endovascular PDT increases the arterial wall strength as measured by the bursting pressure at short‐term. After 1 year, wall strength is not diminished as measured by bursting pressure, but aneurysmal dilatation nevertheless developed with 100 J/cm · dl. This may limit the use of high energy PDT. Lasers Surg. Med. 33:8–15, 2003. © 2003 Wiley‐Liss, Inc.