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Rupture of fat cells using laser‐generated ultra short stress waves
Author(s) -
Kuwahara Kenrick,
Gladstone Hayes B.,
Gupta Vijay,
Kireev Vassili,
Neel Victor,
Moy Ronald L.
Publication year - 2003
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.10154
Subject(s) - materials science , laser , pulse duration , stress (linguistics) , pulse (music) , breakup , stress wave , optics , biomedical engineering , composite material , medicine , psychology , philosophy , linguistics , physics , detector , psychoanalysis
Background and Objectives Ultrasound‐assisted liposuction has been investigated as an aid to breakup fat for its less traumatic removal, and minimizing the post‐operative recovery period. This research focused on understanding the mechanism of fat interaction with laser‐generated ultra short stress waves with high amplitudes. Study Design/Materials and Methods Freshly extracted human fat was secured in an Aluminum (Al) cavity. Sixteen nanoseconds duration stress waves were generated by exfoliating the bottom surface of the Al cavity by focusing 3 nanoseconds‐long YAG laser pulses over a 2 mm diameter area at 10 Hz with a maximum pulse energy of 0.95 J. The lipids released due to cell rupture were extracted and measured Results Four minutes of pulsing released about 0.005 g, which was over 1% of the initial weight of the tissue. In situ temperature rise of only 5°C was measured at the maximum stress wave loading duration of 5 minutes. This was evidenced by histological sections, which showed no burn artifacts. Conclusions This research shows that ultra short stress waves can mechanically cavitate fat in vitro without significant damage to adjacent structures, and forms the basis for future clinical work. Lasers Surg. Med. 32:279–285, 2003. © 2003 Wiley‐Liss, Inc.