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Cancer “photo‐chemoprevention” with pulsed dye laser and celecoxib
Author(s) -
Wang Zhi,
Fuentes Cesar F.,
Shapshay Stanley M.
Publication year - 2003
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.10147
Subject(s) - celecoxib , medicine , cancer , urology
Background and Objectives Our previous study demonstrated the efficacy of pulsed dye laser (PDL) in inhibiting cancer growth. This study is to determine the synergic effect of PDL and Celecoxib, when they are combined for treatment of oral cancer. Study Design/Materials and Methods Fifteen mice were inoculated with oral cell carcinoma and divided into three groups of five each (30 seeding sites/group): (1) control (no treatment), (2) PDL only, and (3) treatment with combined PDL and Celecoxib (1,500 ppm). The number and volume of tumors were counted and measured for 21 days. Results The combined treatment developed tumor at the slowest rate. On day 21, the average tumor volumes were (1) 483.6 mm 3 (control), (2) 312.1 mm 3 (PDL only), and (3) 151.4 mm 3 (combined treatment). Conclusions A synergic effect was found in the combined treatment group. This study provides the first evidence of the efficacy of a new strategy for the treatment of oral cancer, namely, cancer “photo‐chemoprevention.” Lasers Surg. Med. 32:180–184, 2003. © 2003 Wiley‐Liss, Inc.