Tissue welding with biodegradable polymer films–demonstration of acute strength reinforcement  in vivo | Zendy

Sorg Brian S. | Zendy; Welch Ashley J. | Zendy

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Tissue welding with biodegradable polymer films–demonstration of acute strength reinforcement in vivo

Author(s) -

Sorg Brian S.,

Welch Ashley J.

Publication year - 2002

Publication title -

lasers in surgery and medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.888

H-Index - 112

eISSN - 1096-9101

pISSN - 0196-8092

DOI - 10.1002/lsm.10123

Subject(s) - plga , materials science , soldering , in vivo , welding , biomedical engineering , polymer , reinforcement , composite material , lactic acid , nanotechnology , medicine , genetics , microbiology and biotechnology , nanoparticle , bacteria , biology

Background and Objectives To demonstrate, in vivo, acute strength reinforcement benefits of polymer film patches. Study Design/Materials and Methods Full thickness incisions created in a dorsal skin flap of Sprague–Dawley rats were closed by laser‐tissue welding: albumin solder was topically applied to the incision on the dermal surface, and a poly(lactic‐co‐glycolic acid) (PLGA) polymer film placed on the solder as a patch (controls had no film). Breaking strength was tested acutely (15–20 minutes after sacrifice). Results The patched incisions were statistically stronger than the controls (ANOVA, P < 0.05). Conclusions Polymer film patches may be a viable method to increase acute breaking strengths of welds using topically applied solder. Lasers Surg. Med. 31:339–342, 2002. © 2002 Wiley‐Liss, Inc.

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