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Evaluation of pulse‐duration on purpuric threshold using extended pulse pulsed dye laser (cynosure V‐star)
Author(s) -
Tanghetti Emil,
Sierra Rafael A.,
Sherr Evan A.,
Mirkov Mirko
Publication year - 2002
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.10122
Subject(s) - pulse duration , pulse (music) , purpura (gastropod) , fluence , duration (music) , materials science , medicine , optics , laser , physics , biology , ecology , detector , acoustics
Background and Objectives Pulsed dye lasers (PDL) with extended pulse‐durations create new opportunities in the treatment of vascular lesions. Development of extended pulse methods requires understanding of tissue effects of extended pulse‐durations. We evaluated tissue effects of extended pulse‐duration PDL (EPDL) with cooling. Effects of increasing pulse‐duration, fluence, and multiple passes were evaluated to determine purpuric threshold and delayed purpuric response. Study Design/Patients and Methods Ten patients were treated with EPDL and air‐cooling on normal buttocks skin. Exposure pulse‐durations of 0.5, 2, 20, and 40 milliseconds and increasing fluences 3–20 J/cm 2 , pulse‐duration dependent. Exposures were evaluated 0.5, 1, and 24 or 48 hours determining purpuric threshold and side effects. Results Immediate purpuric threshold increased from 6.2 to 8, 10.4, and 13.8 J/cm 2 at pulse‐durations of 0.5, 2, 20, and 40 milliseconds, respectively. Purpuric threshold dropped after 24 hours to 5.2, 7.1, 9.3, and 11.9 J/cm 2 , respectively. Multi‐pass treatment lowered purpuric threshold by 1 J/cm 2 . EPDL purpura resolved in less time than traditional PDL. No side effects were noted. Conclusions EPDL exhibits increasing purpuric threshold with increasing pulse‐durations, and risk of delayed onset of purpura. Lasers Surg. Med. 31:363–366, 2002. © 2002 Wiley‐Liss, Inc.