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Raman spectroscopy for optical diagnosis in normal and cancerous tissue of the nasopharynx—preliminary findings
Author(s) -
Lau David P.,
Huang Zhiwei,
Lui Harvey,
Man Chris S.,
Berean Ken,
Morrison Murray D.,
Zeng Haishan
Publication year - 2003
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.10084
Subject(s) - raman spectroscopy , pathology , laser , cancer , in vivo , nuclear magnetic resonance , medicine , spectroscopy , chemistry , nuclear medicine , optics , biology , physics , microbiology and biotechnology , quantum mechanics
Abstract Background and Objectives Raman spectroscopy (RS), which can detect molecular changes associated with cancer, was explored as a means of distinguishing normal and cancerous nasopharyngeal tissue. Study Design/Patients and Methods Tissue from six patients with normal and cancerous biopsies was studied using a rapid acquisition Raman spectrometer. Results Spectra were obtainable within 5 seconds. Consistent differences were noted between normal and cancer tissue in three bands 1,290–1,320 cm −1 ( P = 0.005), 1,420–1,470 cm −1 ( P = 0.006), and 1,530–1,580 cm −1 ( P = 0.002). Conclusions Spectral differences appear to exist between normal and cancerous nasopharyngeal tissue. The ability to obtain spectra rapidly supports the potential for future in vivo application. Lasers Surg. Med. 32:210–214, 2003. © 2003 Wiley‐Liss, Inc.