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Scanning laser system for photodynamic therapy of choroidal neovascularization
Author(s) -
Obana Akira,
Gohto Yuko
Publication year - 2002
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.10056
Subject(s) - photodynamic therapy , choroidal neovascularization , neovascularization , medicine , laser therapy , ophthalmology , laser , angiogenesis , optics , macular degeneration , cancer research , chemistry , physics , organic chemistry
Background and Objectives In order to improve selectivity of photodynamic therapy (PDT) to choroidal neovascularization (CNV) associated with age‐related macular degeneration, a laser scanning technique was applied to perform focal laser irradiation to the retina, and the occlusion effects of a new device to the choriocapillaris were evaluated in primate eyes. Study Design/Materials and Methods The device contains lasers for fundus observation of 785 nm and for PDT of 670 nm, matching the absorption peak of a photosensitizer, ATX‐S10(Na). The laser irradiated the shape on the retina specified before treatment and shut off automatically when the predetermined treatment was achieved. The occlusion of the choriocapillaris after PDT was documented by fluorescein and indocyanine green angiography and histology. Results The area designated for PDT was easily drawn on the touch‐screen monitor, and occlusion of the choriocapillaris was achieved precisely in the area pre‐selected for treatment with 5 J/cm 2 or more of radiance following administration of 8 mg/kg ATX‐S10(Na). Conclusions This device is useful for irradiating CNV of any shape, sparing the surrounding retina. Since our previous studies suggested that selective occlusion of CNV would decrease not only the functional disturbance caused by PDT, but also the recurrence of CNV, the present device may allow more effective PDT than the slit‐lamp system presently used. Lasers Surg. Med. 30:370–375, 2002. © 2002 Wiley‐Liss, Inc.