Premium
Effects of intense pulsed light on sun‐damaged human skin, routine, and ultrastructural analysis *
Author(s) -
Prieto Victor G.,
Sadick Neil S.,
Lloreta Josep,
Nicholson Judy,
Shea Christopher R.
Publication year - 2002
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.10042
Subject(s) - demodex , wrinkle , intense pulsed light , histology , medicine , dermatology , pathology , ablative case , ultrastructure , biology , surgery , mite , gerontology , botany , radiation therapy
Abstract Background and Objective New, non‐ablative methods can be used in skin rejuvenation. Histologic analysis of non‐ablative IPL effects on facial, sun‐damaged skin. Study Design/Materials and Methods Five female subjects, wrinkle class I or II and Fitzpatrick skin types I, II, and III. IPL treatment: once monthly, 560‐nm cut‐off filters, spot size 8×35 mm, 28–36 J/cm. Routine histology or electron microscopy on 2‐mm punches, before treatment and then 1 week, 3 months, and 12 months. Results Pre‐treatment specimens contained solar elastosis and perifollicular lymphoid infiltrates. Collagen and elastic fibers appeared unaffected by treatment. At 1‐week, Demodex organisms appeared coagulated. Conclusions Under these conditions, IPL induces minimal morphologic changes in mildly sun‐damaged skin. Some esthetic improvement may be secondary to clearing of Demodex organisms and reduction of associated lymphocytic infiltrate. Lasers Surg. Med. 30:82–85, 2002. © 2002 Wiley‐Liss, Inc.