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Vascular procedures that thermo‐coagulate collagen reduce local platelet deposition and thrombus formation: Laser and laser‐thermal versus balloon angioplasty
Author(s) -
Abela George S.,
HageKorban Elie E.,
Tomaru Takanobu,
Barbeau Gérald R.,
Abela Oliver G.,
Friedl Stephan E.
Publication year - 2001
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/lsm.10000
Subject(s) - thrombogenicity , platelet , thrombus , angioplasty , biomedical engineering , medicine , balloon , coagulation , thrombosis , lumen (anatomy) , surgery , materials science , pathology , cardiology
Background and Objective Exposure of the arterial wall matrix to blood leads to platelet deposition resulting in thrombosis. Because heat alters tissue matrix we proposed that heating reduces platelet deposition. Study Design/Materials and Methods Sixty arterial homografts (15 dogs) were mounted in an arterio‐venous “shunt.” Interventions included balloon angioplasty (BA), direct laser (LA), laser‐thermal (LTA), and combined LTABA. 111 Indium‐labeled platelets were circulated, radio activity measured, and homografts processed for histology. Results Radioactivity count (mean ± SE) at BA sites (13,853 ± 3,192 cpm/cm 2 ) was greater than LA (7,038 ± 981), LTA (5,294 ± 1,145), LTABA (6,176 ± 1,571), and control (1,826 ± 339), P < 0.05. Electron microscopy showed fewer platelets at LA, LTA, and control than BA sites. BA spread the collagen on the arterial lumen while heat gelled collagen and confined it to the arterial media. Conclusions Heating the artery and gelling collagen during LA, LTA, or LTABA significantly reduced thrombogenicity. Lasers Surg. Med. 29:455–463, 2001. © 2001 Wiley‐Liss, Inc.