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Rational Design of Ratiometric Luminescence Thermometry Based on Thermally Coupled Levels for Bioapplications
Author(s) -
Suo Hao,
Zhao Xiaoqi,
Zhang Zhiyu,
Wang Yu,
Sun Jiashu,
Jin Minkun,
Guo Chongfeng
Publication year - 2021
Publication title -
laser and photonics reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.778
H-Index - 116
eISSN - 1863-8899
pISSN - 1863-8880
DOI - 10.1002/lpor.202000319
Subject(s) - thermometer , luminescence , materials science , nanotechnology , optoelectronics , lanthanide , cancer therapy , biomedical engineering , medicine , chemistry , cancer , physics , ion , organic chemistry , quantum mechanics
Noninvasive lanthanide‐doped optical thermometers based on fluorescent intensity ratio (FIR) technique have emerged as promising noncontact tools for detecting the inaccessible objects at different scales. Currently, the theoretical and experimental investigations of various influential factors on thermal performances of luminescence thermometers have become one of the hotspots to develop highly sensitive optical thermometers. On the other hand, near‐infrared (NIR) light‐responsive nanothermometers with deep‐tissue penetration have been widely applied for subcutaneous and intracellular thermometry, which could be integrated with optical heating and imaging functions to construct all‐in‐one thermometer‐heater platforms for cancer diagnosis and therapy. In this review, the recent advances in luminescence thermometry based on the thermally coupled levels (TCLs) are elaborately introduced from fundamental aspects to possible biomedical applications, with the perspective and outlook in the emerging challenges of FIR thermometers applied in biomedical science.