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Working with Randy: The Diacylglycerol Acyltransferase Story
Author(s) -
Harwood John L.
Publication year - 2020
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1002/lipd.12267
Subject(s) - carbon flux , flux (metallurgy) , lipidology , diacylglycerol kinase , chemistry , biology , clinical chemistry , biochemistry , enzyme , ecology , protein kinase c , organic chemistry , ecosystem
Vegetable oils are one of the main agricultural commodities. Demand has been increasing steadily over the last five decades and, with finite land available, it is vital that we increase productivity. My laboratory has focused on the regulation of plant lipid metabolism and, as part of this work, we identified diacylglycerol acyltransferase (DGAT) as important at regulating carbon flux during oil accumulation. This led to collaborations with Randy Weselake's research group when we quantified the importance of DGAT in oilseed rape by using flux control analysis. Later, with David Taylor, we showed that over‐expression of DGAT boosted oil accumulation in field‐grown crops by around 8%. These studies led to a multitude of experiments with different oil crops, such as oil palm and soybean, as well as many rewarding collaborations with Randy.