Premium
Ketogenic Diet Based on Extra Virgin Coconut Oil Has No Effects in Young Wistar Rats With Pilocarpine‐Induced Epilepsy
Author(s) -
Melo Isabelle T.,
M. Rêgo Elisabete,
Bueno Nassib B.,
Gomes Tâmara C.,
Oliveira Suzana L.,
TrindadeFilho Euclides M.,
CabralJr. Cyro R.,
Machado Tacy S.,
Galvão Jaqueline A.,
R. Ataide Terezinha
Publication year - 2018
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1002/lipd.12019
Subject(s) - ketogenic diet , pilocarpine , status epilepticus , epilepsy , lipidology , coconut oil , clinical chemistry , medicine , pediatric neurology , endocrinology , chemistry , anesthesia , food science , pediatrics , psychiatry
This study evaluated the effects of a ketogenic diet (KD) based on extra virgin coconut oil ( Cocos nucifera L., VCO), on the treatment of epileptic rats. Two sets of experiments were conducted. First, male Wistar rats underwent induction of status epilepticus (SE) with the administration of pilocarpine intraperitoneally 21 animals reached spontaneous recurrent seizures (SRS) and were randomly allocated to the dietary regimens and video‐monitored for 19 days. In the second experiment, 24 animals were randomized immediately after the induction of SE and followed for 67 days. Diets were as follows: Control (AIN‐93G; 7% lipid), KetoTAGsoya (KD based on soybean oil; 69.79% lipid), and KetoTAGcoco (KD based on VCO; 69.79% lipid). There were no differences in the latency to the first crisis, total frequency, and duration of the SRS between groups in 2 experiments. The data suggest no effects of KD, with or without VCO, in rats with pilocarpine‐induced epilepsy.