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Siphonaxanthin, a Carotenoid From Green Algae, Inhibits Lipogenesis in Hepatocytes via the Suppression of Liver X Receptor α Activity
Author(s) -
Zheng Jiawen,
Li Zhuosi,
Manabe Yuki,
Kim Minji,
Goto Tsuyoshi,
Kawada Teruo,
Sugawara Tatsuya
Publication year - 2018
Publication title -
lipids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.601
H-Index - 120
eISSN - 1558-9307
pISSN - 0024-4201
DOI - 10.1002/lipd.12002
Subject(s) - liver x receptor , lipogenesis , cd36 , fatty acid , retinoid x receptor , sterol regulatory element binding protein , agonist , transcription factor , nuclear receptor , medicine , endocrinology , nonalcoholic fatty liver disease , biochemistry , biology , fatty liver , chemistry , receptor , lipid metabolism , gene , disease
Nonalcoholic fatty liver disease (NAFLD) has shown an increasing morbidity in recent years. Here, we demonstrated that siphonaxanthin (SPX), a rare marine carotenoid, exhibits a strong inhibitory effect on aggravated hepatic lipogenesis in vitro and would be a promising candidate in the prevention and alleviation of NAFLD in the future. In this study, we conducted a preliminary assessment of the effect of SPX on hepatic lipogenesis by using the HepG2 cell line, derived from human liver cancer, as a model of the liver. SPX significantly suppressed the excess accumulation of triacylglycerol induced by liver X receptor α (LXRα) agonist by downregulating a nuclear transcription factor named sterol regulatory element‐binding protein‐1c and a set of related genes. Moreover, fatty acid translocase (CD36) and fatty acid‐binding protein‐1, which regulates fatty acid uptake, also exhibited significant decrease in transcriptional levels. Furthermore, we found that SPX blocked LXRα activation and would be a promising candidate for antagonist of LXRα.