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Efficacy of Transnasal Endoscopic Fine‐Needle Aspiration Biopsy in Diagnosing Submucosal Nasopharyngeal Carcinoma
Author(s) -
Tang QingNan,
Tang LinQuan,
Liu LiTing,
Wen DongXiang,
Lu ZiJian,
Ou GuoPing,
Yan JinJie,
Yang JinHao,
Li JiBin,
Wen YueFeng,
Guo ShanShan,
Liu SaiLan,
Xie HaoJun,
Sun XueSong,
Li XiaoYun,
Chen QiuYan,
Mai HaiQiang
Publication year - 2021
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.29433
Subject(s) - medicine , nasopharyngeal carcinoma , biopsy , fine needle aspiration , radiology , otorhinolaryngology , mucositis , surgery , radiation therapy
Objectives/Hypothesis The routine practices of examining submucosal lesions are not suitable for deep lesions. Therefore, we evaluated the efficacy of non‐real‐time image‐guided transnasal endoscopic fine‐needle aspiration biopsy (FNAB) in diagnosing nasopharyngeal carcinoma (NPC) with submucosal lesions. Study Design The effectiveness evaluation of diagnostic methods. Methods Fifty suspected NPC patients who failed in conventional biopsies were enrolled in this study. The efficacy, maneuverability, and safety of FNAB in diagnosing these intractable cases were evaluated. Results The definitive diagnostic results of these 50 patients were NPC (34/50, 68.0%), nasopharyngeal necrosis (1/50, 2.0%), nasopharyngeal mucositis (12/50, 24.0%), and other cancers (3/50, 6.0%), respectively. The results of the diagnostic efficacy of FNAB were sensitivity, 89.2%; specificity, 100.0%; positive predictive value, 100.0%; negative predictive value, 76.5%; and accuracy, 92.0%, respectively. The area under the receiver operating characteristic curves was 0.946 (95% confidence interval = 0.884–1.00, P < .001). No severe complications occurred after FNAB. Conclusions FNAB can improve the diagnostic efficiency of NPC occurring in the submucosal space. It can be an additional option for routine nasopharyngeal biopsy and is worthy of clinical application. Level of Evidence 4 Laryngoscope , 131:1798–1804, 2021