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Prognostic Significance of Systemic Inflammatory Response in Cases of Temporal Bone Squamous Cell Carcinoma
Author(s) -
Komune Noritaka,
Sato Kuniaki,
Hongo Takahiro,
Miyazaki Masaru,
Masuda Shogo,
Koike Kensuke,
Uchi Ryutaro,
Tsuchihashi Nana Akagi,
Noda Teppei,
Kogo Ryunosuke,
Wakasaki Takahiro,
Yasumatsu Ryuji,
Nakagawa Takashi
Publication year - 2021
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.29421
Subject(s) - medicine , systemic inflammation , stage (stratigraphy) , univariate analysis , oncology , malignancy , proportional hazards model , multivariate analysis , head and neck squamous cell carcinoma , pathology , inflammation , cancer , head and neck cancer , paleontology , biology
Objective/Hypothesis Squamous cell carcinoma (SCC) of the temporal bone is an extremely rare condition. This rarity has led to a delay in the establishment of a standard treatment protocol and adequate staging system. Identification of prognostic markers of this disease from a variety of fields is desirable in the establishment of treatment guidelines for temporal bone SCC. The aim of this study is to assess the prognostic role of inflammation‐based prognostic scores in cases of temporal bone SCC. Study Design Case reries with chart review. Methods A total of 71 cases of primary malignancy eligible for curative treatment at a single tertiary medical institute were retrospectively analyzed. Univariate and multivariate regression analyzes were used to investigate the association between the inflammation‐based scores and 5‐year overall survival. Results Univariate Cox regression analyzes showed that a high neutrophil‐to‐lymphocyte ratio, high platelet‐to‐lymphocyte ratio, low lymphocyte‐to‐monocyte ratio, a Glasgow prognostic score of 2, and the systemic inflammation score of 2 were significantly associated with a poor prognosis, as well as a classification of T4 stage, presence of cervical lymph node metastasis, high white blood cell counts, and high C‐reactive protein levels. The multivariate analysis showed that a clinical stage of T4 and a systemic inflammation score of 2 were independent prognostic markers. Conclusions Inflammation‐based prognostic markers are associated with the survival of patients with temporal bone SCC, as well as other head and neck SCCs. Level of Evidence 4 Laryngoscope , 131:1782–1789, 2021