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Autofluorescence and Indocyanine Green in Thyroid Surgery: A Systematic Review and Meta‐Analysis
Author(s) -
Barbieri Diego,
Indelicato Pietro,
Vinciguerra Alessandro,
Marco Federico,
Formenti Anna Maria,
Trimarchi Matteo,
Bussi Mario
Publication year - 2021
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.29297
Subject(s) - medicine , meta analysis , hypoparathyroidism , thyroidectomy , thyroid , systematic review , surgery , medline , political science , law
Objectives/Hypothesis To estimate the impact of optical techniques on prevention of post‐operative hypocalcemia and hypoparathyroidism after total thyroidectomy. Study Design Systematic review and meta‐analysis. Methods A literature search was conducted in Pubmed, EMBASE, SCOPUS, and Cochrane databases. The main inclusion criteria for eligible articles for meta‐analysis were patients with benign or malignant thyroid pathologies who underwent total thyroidectomy, utilization of optical techniques to support PGs preservation, the availability of calcium and/or PTH levels. The primary outcome was to evaluate the variation of calcium and PTH levels when adopting optical technologies compared to standard naked‐eye surgery. Results In total, 13 papers with 1484 procedures were included. Pooled proportion for short‐ and medium‐term hypocalcemia rates were 8% (95% CI, 5%:11%) and 1% (95% CI, 0%:4%) for optical techniques, while for naked‐eye surgery were 15% (95% CI, 9%:23%) and 5% (95% CI, 2%:9%), respectively. Conclusions Optical technologies reduced short and medium term hypocalcemia compared to conventional surgery. Level of Evidence NA Laryngoscope , 131:1683–1692, 2021