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Multi‐institutional Survey of Squamous Cell Carcinoma of the External Auditory Canal in Japan
Author(s) -
Shiga Kiyoto,
Nibu Kenichi,
Fujimoto Yasushi,
Asakage Takahiro,
Homma Akihiro,
Mitani Hiroki,
Ogawa Takenori,
Okami Kenji,
Murono Shigeyuki,
Hirano Shigeru,
Ueda Tsutomu,
Hanai Nobuhiro,
Tsukahara Kiyoaki,
Ota Ichiro,
Yoshimoto Seiichi,
Shinozaki Takeshi,
Iwae Shigemichi,
Katagiri Katsunori,
Saito Daisuke,
Kiyota Naomi,
Tahara Makoto,
Takahashi Fumiaki,
Hayashi Ryuichi
Publication year - 2021
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.28936
Subject(s) - medicine , docetaxel , regimen , head and neck cancer , chemoradiotherapy , cisplatin , fluorouracil , auditory canal , basal cell , retrospective cohort study , oncology , overall survival , cancer , surgery , chemotherapy
Objectives This study aimed to evaluate the efficacy of chemoradiotherapy (CRT) for patients with advanced cancer of the external auditory canal (EAC) by analyzing the outcome of the patients. Methods This is a multi‐institutional retrospective survey, and we reviewed the medical records of the subjects. A total of 181 patients with tumor (T)3 or T4 tumor in 17 institutions were enrolled. Further analysis was performed for 74 patients who underwent CRT under curative intent. Results Overall 5‐year survival rates of the patients who underwent CRT (n = 74) were 54.6%. Those of the patients who underwent CRT with modified TPF (docetaxel, cisplatin [CDDP], and 5‐fluorouracil) regimen (n = 50) and CRT with CDDP regimens (n = 24) were 64.4% and 36.7%, respectively. Significant differences were observed between these two groups. Conclusion Given the tendency that head and neck surgeons prefer CRT for advanced larger cancer of the EAC, CRT for advanced EAC cancer using the modified TPF regimen showed good clinical outcomes. Level of Evidence 4 Laryngoscope , 131:E870–E874, 2021