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Intraoperative Fluorescence‐Guided Surgery in Head and Neck Squamous Cell Carcinoma
Author(s) -
Lee YuJin,
Krishnan Giri,
Nishio Naoki,
Berg Nynke S.,
Lu Guolan,
Martin Brock A.,
Keulen Stan,
Colevas Alexander D.,
Kapoor Shrey,
Liu Jonathan T.C.,
Rosenthal Eben L.
Publication year - 2021
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.28822
Subject(s) - medicine , head and neck cancer , head and neck , fluorescence lifetime imaging microscopy , head and neck squamous cell carcinoma , basal cell , radiology , cancer , surgery , oncology , fluorescence , pathology , physics , quantum mechanics
The rate of positive margins in head and neck cancers has remained stagnant over the past three decades and is consistently associated with poor overall survival. This suggests that significant improvements must be made intraoperatively to ensure negative margins. We discuss the important role of fluorescence imaging to guide surgical oncology in head and neck cancer. This review includes a general overview of the principles of fluorescence, available fluorophores used for fluorescence imaging, and specific clinical applications of fluorescence‐guided surgery, as well as challenges and future directions in head and neck surgical oncology. Laryngoscope , 131:529–534, 2021