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Prevalence of Synchronous ESCN in Head and Neck Cancer: A Single‐Institution Perspective
Author(s) -
Thakur Kuldeep,
Singh Chirom A.,
Thakar Alok,
Kakkar Aanchal,
Sikka Kapil,
Kumar Rajeev,
Sharma Suresh C.
Publication year - 2021
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.28821
Subject(s) - medicine , head and neck squamous cell carcinoma , larynx , pyriform sinus , carcinoma , head and neck cancer , gastroenterology , oncology , cancer , pathology , radiology , surgery , fistula
Objectives The primary objective was to determine the prevalence of synchronous esophageal squamous cell carcinoma in head and neck squamous cell carcinoma (HNSCC) patients. The secondary objective was to determine risk factors for the development of synchronous esophageal squamous cell carcinoma (ESCN). Study Design: Cross sectional observation study. Methods A prospective cross sectional, observational study on consecutive 300 newly diagnosed oral cavity, oropharynx, hypopharynx, and laryngeal squamous cell carcinoma patients who underwent trans‐nasal esophageal endoscopy with white light imaging and narrow band imaging. Results Among 300 patients, index HNSCCs were located in the oral cavity (n = 154, 51.3%), oropharynx (n = 63, 21%), larynx (n = 53, 17.7%), and hypopharynx (n = 30, 10%). The prevalence of synchronous ESCN was 2.7% (n = 8), including four low‐grade, two high‐grade dysplasia, and two squamous cell carcinomas. On logistic regression analysis, moderate to heavy alcohol consumption (OR 8.7, P = .01) and primary HNSCC involving supraglottis [(OR 12.5, P = .02) were risk factors for synchronous ESCN. The association of pyriform sinus carcinoma and synchronous ESCN was of borderline significance ( P = .054, OR 10.92). Conclusion The prevalence of synchronous ESCN in HNSCC was 2.7%. Routine trans‐nasal esophagoscopy should be performed in all newly diagnosed patients with carcinoma of the supraglottis and pyriform sinus, and those with consumption of moderate to heavy alcohol for the screening of synchronous ESCN. Level of Evidence 2b Laryngoscope , 131:E807–E814, 2021