Premium
Genetics of Postlingual Sensorineural Hearing Loss
Author(s) -
Ahmadmehrabi Shadi,
Brant Jason,
Epstein Douglas J.,
Ruckenstein Michael J.,
Rader Daniel J
Publication year - 2021
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.28646
Subject(s) - presbycusis , hearing loss , medicine , sensorineural hearing loss , genetics , family history , disease , audiology , age of onset , bioinformatics , biology
Literature and clinical practice around adult‐onset hearing loss (HL) has traditionally focused on environmental risk factors, including noise exposure, ototoxic drug exposure, and cardiovascular disease. The most common diagnosis in adult‐onset HL is presbycusis. However, the age of onset of presbycusis varies, and patients often describe family history of HL as well as individual variation in progression and severity. In recent years, there has been accumulating evidence of gene–environment interactions underlying adult cases of HL. Susceptibility loci for age‐related HL have been identified, and genes related to postlingual nonsyndromic HL continue to be discovered through individual reports and genome‐wide association studies. This review will outline main concepts in genetics as related to HL, identify implicated genes, and discuss clinical implications. Laryngoscope , 131:401–409, 2021