Premium
Head and Neck Dystonia Following Chimeric‐Antigen Receptor T‐Cell Immunotherapy: A Case Report
Author(s) -
Lee Daniel D.,
Lin Yufan,
Galati Lisa T.,
Shapshay Stanley M.
Publication year - 2020
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.28585
Subject(s) - chimeric antigen receptor , medicine , immunotherapy , lymphoma , refractory (planetary science) , dystonia , oncology , focal dystonia , head and neck , antigen , immunology , immune system , surgery , biology , psychiatry , astrobiology
Chimeric antigen receptor T‐cell therapy (CAR‐T) is a novel immunotherapy used for the treatment of refractory B‐cell leukemias and lymphoma. As clinical trials continue to expand, multiple treatment toxicities have been documented. Treatment‐associated toxicities are typically systemic, however, focal manifestations have been described. We present a unique case of a 55‐year‐old female who developed oropharyngeal and laryngeal dystonia following CAR‐T therapy. This case points to a possible association between CAR‐T therapy and focal head and neck dystonia. Laryngoscope , 2020