Premium
The Correlation Between Endolymphatic Hydrops and Clinical Features of Meniere Disease
Author(s) -
Zhang Weidong,
Hui Lian,
Zhang Bo,
Ren Ling,
Zhu Jingyi,
Wang Fei,
Li Songbai
Publication year - 2021
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.28576
Subject(s) - endolymphatic hydrops , meniere's disease , endolymph , medicine , vertigo , perilymph , tinnitus , magnetic resonance imaging , cochlea , audiology , pure tone audiometry , radiology , audiometry , hearing loss , surgery
Objectives The purpose of this study was to investigate the grades of endolymphatic hydrops determined by gadolinium‐contrast magnetic resonance (MR) and correlation to the clinical features in patients with Meniere disease. Study Design Prospective study. Methods A total of 24 patients suffering from unilateral Meniere disease with either definite or probable clinical diagnosis were included. The duration of vertigo, duration of tinnitus, duration of vertigo attacks, hearing thresholds, and canal paresis (CP) value of caloric tests were assessed. Three‐dimensional fluid‐attenuated inversion recovery magnetic resonance imaging (MRI) was performed 4 hours after intravenous injection of double dose of gadobutrol (Gd) to show endolymph and perilymph, and the grades of endolymphatic hydrops were measured. Additionally, the correlation between clinical features and the grades of endolymphatic hydrops of cochlea and vestibular were evaluated. Results Different grades of the endolymphatic hydrops in the impaired ear were revealed by MRI. The Spearman correlation showed a strong correlation between the hearing thresholds of low, middle, and high tone and the grades of cochlea and vestibular hydrops ( P < .05); However, no significant correlation between the duration of vertigo, duration of tinnitus, duration of vertigo attacks, CP value, and endolymphatic hydrops was determined ( P > .05). Conclusion By visualizing the endolymph and perilymph of inner ear in patients with Meniere disease assisted with intravenous injection of double doses of Gd, the grades of endolymphatic hydrops could be assessed. As a result, the grades of endolymphatic hydrops in patients with Meniere disease can be used to predict the level of hearing impairment. Level of Evidence 4 Laryngoscope , 131:E144–E150, 2021