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Ectopic cervical thymus in children: Clinical and radiographic features
Author(s) -
Purcell Patricia L.,
Marquez Garcia Juan,
Zawawi Faisal,
Propst Evan J.,
Papsin Blake C.,
Blaser Susan I.,
Wolter Nikolaus E.
Publication year - 2020
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.28248
Subject(s) - medicine , ectopic thyroid , ultrasound , radiology , magnetic resonance imaging , lesion , radiography , malignancy , thyroid , retrospective cohort study , neuroradiology , pathology , neurology , psychiatry
Objectives Ectopic thymus is rare and can be a diagnostic challenge. This study evaluated the management of children radiographically diagnosed with ectopic cervical thymus. Methods A retrospective review of 100 patients was performed. Data related to clinical presentation, radiological imaging, pathology, and management were collected. Changes in lesion volume were tracked over time. Clinical characteristics were compared based on lesion location in the neck using analysis of variance modelling. Results There were 115 lesions with radiographic features of ectopic cervical thymus (15 children had bilateral lesions). Diagnosis was based on ultrasound in 98% of patients, magnetic resonance imaging in 18%, and computed tomography in 11%. Mean (SD) follow‐up duration was 2 (2.2) years. Forty‐four percent (51/115) of lesions involved the thyroid gland, 29% (33/115) were in the central neck but separate from the thyroid, 18% (21/115) had mediastinal extension, and 8% (9/115) involved the submandibular region. Location was unclear for two patients. Submandibular lesions were on average 12.4 cm 3 larger (95% CI, 8.2, 16.6) than mediastinal lesions at diagnosis, P ≤ .001. Volume of thymic tissue decreased over time, from a mean (standard deviation [SD]) volume of 4.3 cm 3 (9.2) at initial ultrasound to 2.7 cm 3 (6.1) at final ultrasound (paired t‐test, P = .008). Only two patients required surgery: one for compressive symptoms, and the other to rule out malignancy. Conclusion Ninety‐eight percent of children with ectopic cervical thymus were managed conservatively without issues. We propose a classification system based on location to ease communication among clinicians and to help follow these lesions over time. Level of Evidence 4, case series Laryngoscope, 130:1577–1582, 2020