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Does Thyroid Gland Preserving Total Laryngectomy Affect Oncological Control in Laryngeal Carcinoma?
Author(s) -
McGuire Jessica K.,
Viljoen Gerrit,
Rocke John,
Fitzpatrick Siobhan,
Dalvie Sameera,
Fagan Johannes J.
Publication year - 2020
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.28235
Subject(s) - medicine , laryngectomy , thyroid , thyroid cancer , thyroidectomy , thyroid carcinoma , larynx , stage (stratigraphy) , retrospective cohort study , surgery , cancer , paleontology , biology
Thyroid lobectomy is recommended with total laryngectomy in the National Comprehensive Cancer Network guidelines. However, it is associated with a 32% to 89% risk of hypothyroidism, which is a problem for patients without access to thyroid hormone monitoring and replacement. A number of studies have reported a low incidence of thyroid gland involvement and recommended preserving the thyroid gland in favorable cases. Yet there are no studies that report whether thyroid preserving laryngectomy for laryngeal cancer adversely affects oncologic outcomes compared to patients who have undergone thyroid lobectomy. Objectives To determine whether patients who underwent thyroid gland preserving laryngectomy had higher local recurrence rates or poorer disease‐free survival. Method A retrospective folder review of patients who underwent a total laryngectomy over a 12‐year period was conducted. Local recurrence and disease‐free survival were determined for patients who had both their thyroid lobes preserved and compared with those who had a thyroid lobectomy. Results Sixty‐nine patients had thyroid preserving laryngectomy and 73 patients had a thyroid lobectomy. The duration of follow‐up was 18 to 132 months (median, 30; IQR, 30). There was no significant difference in local recurrence rates ( P = .76) or survival curves between the two groups. Conclusion Thyroid preserving laryngectomy in selected patients with advanced laryngeal carcinoma does not increase local recurrence rates, nor does it negatively affect disease‐free survival. Thyroid preservation is appropriate when intraoperative inspection of the larynx shows no extralaryngeal extension or when paratracheal nodal metastases are not a concern. Level of Evidence Level 4 Laryngoscope, 130:1465–1469, 2020