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Pediatric airway tumors: A report from the International Network of Pediatric Airway Teams (INPAT)
Author(s) -
Pio Luca,
Varela Patricio,
Eliott Martin J.,
Couloigner Vincent,
Guillén Burrieza Gabriela,
Paraboschi Irene,
Virgone Calogero,
Maunsell Rebecca,
Rachkov Victor,
Rutter Michael J.,
Boglione Mariano,
Penchyna Grub Jaime,
Bellía Munzón Gastón,
Sarnacki Sabine,
Irtan Sabine,
Schweiger Claudia,
Larroquet Michèle,
Khen Dunlop Naziha,
Ramaswamy Madhavan,
Pistorio Angela,
Cecchetto Giovanni,
Ferrari Andrea,
Bisogno Gianni,
Torre Michele
Publication year - 2020
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.28062
Subject(s) - medicine , malignancy , presentation (obstetrics) , airway , mucoepidermoid carcinoma , carcinoid tumors , retrospective cohort study , pediatrics , pathology , surgery , carcinoma
Objective Primary tracheobronchial tumors (PTTs) are rare heterogeneous lesions arising from any part of the tracheobronchial tree. Nonspecific symptoms may lead to delayed diagnosis that requires more aggressive surgical treatment. An analysis of cases collected by the International Network of Pediatric Airway Team was undertaken to ensure proper insight into the behavior and management of PTTs. Methods Patients <18 years of age with a histological confirmation of PTT diagnosed from 2000 to 2015 were included in this multicenter international retrospective study. Medical records, treatment modalities, and outcomes were analyzed. The patient presentation, tumor management, and clinical course were compared between malignant and benign histotypes. Clinical and surgical variables that might influence event‐free survival were considered. Results Among the 78 children identified, PTTs were more likely to be malignant than benign; bronchial carcinoid tumor (n = 31; 40%) was the most common histological subtype, followed by inflammatory myofibroblastic tumor (n = 19; 25%) and mucoepidermoid carcinoma (n = 15; 19%). Regarding symptoms at presentation, wheezing ( P = 0.001) and dyspnea ( P = 0.03) were more often associated with benign growth, whereas hemoptysis was more frequently associated with malignancy ( P = 0.042). Factors that significantly worsened event‐free survival were age at diagnosis earlier than 112 months ( P = 0.0035) and duration of symptoms lasting more than 2 months ( P = 0.0029). Conclusion The results of this international study provide important information regarding the clinical presentation, diagnostic workup, and treatment of PTTs in children, casting new light on the biological behavior of PTTs to ensure appropriate treatments. Level of Evidence NA Laryngoscope , 130:E243–E251, 2020