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Congenital laryngomalacia: Is it an inflammatory disease? The role of vitamin D
Author(s) -
Hassan Megahed M.,
Emam Ahmed M.,
Mahmoud Ahmed M.,
Awad Al Husseiny,
Rezk Ibrahim,
AbouTaleb Ashraf,
Mohamed Montasser M.,
ElMagd Essam A. A.
Publication year - 2020
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.27997
Subject(s) - laryngomalacia , medicine , stridor , gastroenterology , vitamin d and neurology , pediatrics , anesthesia , airway
Objectives/Hypothesis Laryngomalacia is the most common cause of stridor in infants. The exact pathophysiology is still not well understood. Our objective was to investigate whether laryngomalacia is an inflammatory disease, focusing on the possible role of vitamin D. Study Design Case‐control study. Methods Sixty Egyptian infants and 60 mothers were included in this study. They were divided into four equal groups (n = 30 for each): infants with laryngomalacia (LM‐infants), control infants (C‐infants), mothers of the infants with laryngomalacia (LM‐mothers), and mothers of the control infants (C‐mothers). Laryngoscopy was performed and serum 25‐hydroxyvitamin D (25[OH]‐vitamin‐D) and interleukin 6 (IL‐6) were estimated. Results Significant increase of serum IL‐6 associated with a significant decrease in serum 25(OH)‐vitamin D was observed in the LM‐infants compared to the C‐infants ( P < .001 for both). LM‐mothers had significantly lower 25(OH)‐vitamin D status compared to C‐mothers ( P < .001). Conclusions Deficiency of 25(OH)‐vitamin D in LM‐infants may result in dysregulation of the immune responses with elevation of a proinflammatory cytokine (IL‐6). Laryngomalacia could be an inflammatory disease due to 25(OH)‐vitamin D deficiency as evidenced by the high level of IL‐6. This finding may open the door to the appropriate prevention, diagnosis, and treatment, especially for moderate to severe laryngomalacia. Level of Evidence 3b Laryngoscope , 130:448–453, 2020