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Deep neuromuscular blockade for endolaryngeal procedures: A multicenter randomized study
Author(s) -
Laosuwan Prok,
Songarj Phuriphong,
Lapisatepun Worawut,
Boonsri Settapong,
Rodanant Oraluxna,
Wasinwong Wirat,
Sriraj Wimonrat,
Watcharotayangul Jittiya,
Wongyingsinn Mingkwan
Publication year - 2020
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.27956
Subject(s) - neuromuscular blockade , blockade , medicine , multicenter study , randomized controlled trial , anesthesia , receptor
Objectives/Hypothesis The aim of the present study was to compare the surgical condition between deep neuromuscular blockade (NMB) and moderate NMB. Study Design Multicenter, randomized, parallel intervention trial. Methods One hundred two patients underwent microscopic endolaryngeal surgery at four university hospitals. The patients were randomized into moderate NMB (train‐of‐four 1‐2) (M group) or deep NMB (post‐tetanic count 1‐2) (D group) with moderate or high doses of rocuronium, respectively. Surgical rating conditions (SRCs) were evaluated during the surgery. Sugammadex was given to the M group at 2 mg/kg and the D group at 4 mg/kg. Perioperative clinical signs and conditions were recorded until discharge from the postanesthesia care unit. Results Clinically acceptable SRC was observed in 49 patients (100%) in the D group and 43 patients (89.6%) in the M group ( P = .027). The frequency of notable vocal fold movement in the M group was significantly higher than the D group (70.8% vs. 32.7%). The patients in the M group required more additional doses of rocuronium (47.9%) than the D group (20.4%) to maintain full relaxation ( P = .005). The median time (interquartile range) from administration of sugammadex to train‐of‐four ratio 0.9 in the D group was shorter than the M group (120 [109–180 minutes] vs. 180 minutes [120–240 minutes], P = .034). Conclusions Deep NMB with high doses of rocuronium combined with 4 mg/kg of sugammadex for reversal during endolaryngeal surgery provided better SRC and anesthetic conditions than moderate NMB of rocuronium with 2 mg/kg of sugammadex. Level of Evidence 1b Laryngoscope , 130:437–441, 2020