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Wound Complications in Head and Neck Squamous Cell Carcinomas After Anti–PD‐1 Therapy
Author(s) -
Hwang Victoria,
Mendez Eduardo,
Chow Laura Q. M.,
Futran Neal David,
Andersen Peter,
Li Ryan,
Divi Vasu,
Rodriguez Cristina P.
Publication year - 2019
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.27902
Subject(s) - medicine , osteoradionecrosis , craniofacial , mandible (arthropod mouthpart) , surgery , lesion , head and neck cancer , head and neck , radiation therapy , basal cell , cancer , botany , psychiatry , biology , genus
Immune checkpoint inhibitors have demonstrated activity in recurrent/metastatic head and neck squamous cell cancer, but less is known regarding their long‐term sequelae. We describe four patients who, after complete responses to anti–PD‐1 therapy, developed complications requiring surgical intervention. Patient 1 is a 57‐year‐old female whose marked tumor regression exposed some mandibular hardware. Patient 2 is a 39‐year‐old male who developed an ulcerated buccal lesion with exposed mandible. Patient 3 is a 66‐year‐old male with craniofacial osteoradionecrosis. Patient 4 is a 71‐year‐old male who developed an exposed and fractured mandible. All patients successfully underwent surgical intervention and remain disease free. Laryngoscope , 129:E428–E433, 2019