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Qualitative and quantitative scintigraphy in sialorrhea before and after botulinum toxin injection
Author(s) -
Ribeiro Livia Barroso,
Xerez Denise Rodrigues,
Maliska Carmelindo,
Souza Sergio Augusto Lopes,
Costa Milton Melciades Barbosa
Publication year - 2019
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.27826
Subject(s) - sialorrhea , botulinum toxin , saliva , medicine , parotid gland , toxin , pharmacology , chemistry , anesthesia , pathology , biochemistry
Objectives/Hypothesis Sialorrhea is excessive saliva production and its usual escape of from the oral cavity. The use of botulinum toxin has been preconized, but its effectiveness until now has been unreliably measured. Our objective was to qualitatively and quantitatively determine the effectiveness of botulinum toxin injection in the reduction of saliva production by the parotid gland. Study Design Outcomes research. Methods Patients with moderate‐to‐critical sialorrhea had one of the parotid glands injected with 50 U of botulinum toxin, leaving the other as the control. Fifteen days after the toxin injection, they underwent scintigraphic analyses with intravenous injection of 10 mCi (37 MBq) of Tc‐99 m (sodium pertechnetate). After this, the noninjected gland was treated for therapeutic complementation. Results The glands injected with botulinum toxin showed uptake reduction in 100% of patients. The uptake reduction in counts per second varied from 8% to 36%. The Wilcoxon paired test comparing the control glands with those injected showed a significant difference for the action of botulinum toxin ( P = .0039). Conclusions The scintigraphic study of parotid glands shows that botulinum toxin is effective in reducing sodium pertechnetate uptake. Level of Evidence 2c Laryngoscope , 129:2521–2526, 2019