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Significance of intraparotid node metastasis in predicting local control in primary parotid cancer
Author(s) -
Feng Yanping,
Liu Fei,
Cheng Guangyan,
Fang Qigen,
Niu Xinyu,
He Wei
Publication year - 2019
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.27701
Subject(s) - medicine , metastasis , perineural invasion , lymphovascular invasion , t stage , stage (stratigraphy) , oncology , cancer , gastroenterology , pathology , biology , paleontology
Objective To analyze the metastasis rate in intraglandular lymph nodes (IGLNs) with a focus on discussing the significance of IGLN metastasis in local control (LC) of parotid gland cancer (PGC). Methods A total of 337 patients were enrolled. Information including age; sex; and pathologic variables such as tumor (T) stage, IGLN metastasis, and follow‐up findings was extracted and analyzed. Results IGLN metastasis was noted in 111 (32.9%) patients. Tumor stage, pathologic nodal stage, perineural invasion, resection status, and lymphovascular invasion were significantly related to IGLN metastasis. Local recurrence was noted in 67 (19.9%) patients. IGLN metastasis was an independent predictor of LC. The 10‐year LC rate was 94% for patients without IGLN metastasis, 56% for patients with metastasis in no more than two IGLNs, and 22% for patients with metastasis in more than two IGLNs. This difference was significant ( P < 0.001). Conclusion The IGLN metastasis rate is relatively high in PGC patients and is significantly associated with disease grade and T stage. IGLN metastasis is associated with poorer local LC, and patients with more than two metastatic nodes have the worst prognosis. Level of Evidence 4 Laryngoscope , 129:2309–2312, 2019