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Laryngeal distribution of adult‐onset recurrent respiratory papillomatosis: A longitudinal study
Author(s) -
Hu Lizbeth,
Benedict Peter A.,
Garber David,
Wang Binhuan,
Amin Milan R.,
Branski Ryan C.
Publication year - 2019
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.27694
Subject(s) - medicine , recurrent respiratory papillomatosis , glottis , papillomatosis , lesion , larynx , surgery , respiratory system , respiratory disease , retrospective cohort study , univariate analysis , multivariate analysis , pathology , lung
Objectives/Hypothesis To describe recurrence patterns in patients with recurrent respiratory papillomatosis (RRP) following surgical intervention. Study Design Single‐center, retrospective, longitudinal case series. Methods Initial and follow‐up laryngoscopic examinations of seven previously untreated adult‐onset RRP patients were reviewed. Patients were followed longitudinally for periods ranging from 3 months to 7 years. Lesion locations were recorded using a twenty‐one region laryngeal schematic, and maps were generated to illustrate the distribution of disease before and after cold‐knife or potassium‐titanyl‐phosphate laser intervention. Univariate and multivariate analyses were employed to examine variables affecting recurrence patterns. Results Across all patients, a statistically significant correlation between initial distribution and primary recurrence was observed. Seventy‐five percent of new lesions were adjacent to regions with preexisting disease; 83% of new glottic lesions were adjacent to preexisting glottic lesions, and 66% of supraglottic lesions were adjacent to preexisting supraglottic regions. No statistically significant differences in recurrence rate were observed across sites. Conclusions In previously untreated patients with adult‐onset recurrent respiratory papillomatosis, lesions tended to recur either in the same regions or regions adjacent to those affected at the time of initial surgery. Level of Evidence 4 Laryngoscope , 129:1993–1997, 2019