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Radiographic muscle invasion not a recurrence predictor in HPV ‐associated oropharyngeal squamous cell carcinoma
Author(s) -
Farzal Zainab,
Du Eugenie,
Yim Eunice,
Mazul Angela,
Zevallos Jose P.,
Huang Benjamin Y.,
Hackman Trevor G.
Publication year - 2019
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.27351
Subject(s) - medicine , radiography , retrospective cohort study , otorhinolaryngology , radiology , surgery
Objective To determine whether muscle invasion evident on pretreatment imaging in p16 + oropharyngeal squamous cell carcinoma (OPSCC) correlates with recurrence. Study Design Retrospective review. Methods Two‐hundred and seventy‐six patients with p16 + OPSCC treated at a tertiary referral center from 2003 to 2015 were analyzed. All scans were reviewed by a dedicated neuroradiologist with subspecialty expertise in head and neck imaging. Radiographic evidence of muscle invasion to the genioglossus, hyoglossus, medial pterygoid, and prevertebral muscles was analyzed. Local and regional recurrence rates were compared between the muscle invasion and no muscle invasion groups. Results One hundred and ninety patients met inclusion criteria with adequate follow‐up data and pretreatment imaging. Patients were predominantly male (87.5% male) and smokers (65.6% smokers) with a mean age of 56.7 (standard deviation: 9.0 years). Most commonly invaded muscles in the muscle invasion group were hyoglossus (57.8%) and genioglossus (56.3%). There was no statistically significant difference in primary site or nodal recurrence between the combined group, including definite or possible muscle invasion and the group without muscle invasion ( P = 0.205 and P = 0.569, respectively). Additionally, no statistically significant difference was present in recurrence‐free and disease‐specific survival between the two groups at 3‐ and 5‐year follow‐up ( P > 0.05). Conclusion Radiographic evidence of muscle invasion does not appear to be a predictor of human papilloma virus (+) OPSCC recurrence. Additional studies are needed to validate our findings. Level of Evidence 4 Laryngoscope , 129:871–876, 2019