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Endoscopic sentinel lymph node biopsy using indocyanine green‐neomannosyl human serum albumin
Author(s) -
Park Young Min,
Quan Yu Hua,
Kwon Ki Hyeok,
Cho JaeGu,
Woo JeongSoo,
Kim BeopMin,
Lee YunSang,
Jeong Jae Min,
Kim Hyun Koo,
Song JaeJun
Publication year - 2018
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.27036
Subject(s) - indocyanine green , sentinel lymph node , lymph , medicine , biopsy , lymph node , endoscope , sentinel node , radiology , tongue , lymph node biopsy , pathology , cancer , breast cancer
Objective The aim of this study was to determine the possibility of endoscopic sentinel lymph node biopsy of the head and neck region using indocyanine green‐neomannosyl human serum albumin (ICG:MSA) and a custom‐made intraoperative color‐and‐fluorescence‐merged imaging system (ICFIS). Methods Using mouse and rabbit models of tongue cancer, we performed sentinel lymph node biopsy using an ICG:MSA tracer and custom imaging system equipped with an endoscope. Results ICG:MSA was localized to the cervical lymph node on the ipsilateral side for up to 30 minutes compared to ICG tracer (ICG n = 3, IGC:MSA n = 3). Detection of sentinel lymph nodes was attempted after injecting ICG:MSA in the mouse tongue cancer model (n = 3). During the operation, lymph nodes were easily identified and resected using ICFIS without the aid of other magnifiers. In the rabbit tongue cancer model (n = 3), the ICFIS equipped with 30‐degree endoscopy was used to confirm the feasibility of endoscopic sentinel lymph node biopsy. The entire sentinel lymph node biopsy procedure was performed using the ICFIS with the 30‐degree endoscope. We detected and dissected sentinel lymph nodes in the rabbit model without the other sentinel lymph node detection tools. Conclusion We confirmed the usefulness of sentinel lymph node biopsy using a near infrared fluorescence technique and endoscopic system. Avoidance of radiation exposure and shine‐through phenomena, which are problems of sentinel lymph node biopsy using conventional radioisotopes, are advantages of our surgical technique. By combining the endoscopic system with a sentinel lymph node biopsy procedure, we avoided visible neck scars, which lead to excellent cosmetic outcomes. Level of Evidence NA. Laryngoscope , 128:E135–E140, 2018