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The effectiveness of platelet‐rich plasma in an anosmia‐induced mice model
Author(s) -
Yasak Ahmet Gorkem,
Yigit Ozgur,
Araz Server Ela,
Durna Dastan Sevgi,
Gul Mehmet
Publication year - 2018
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.27029
Subject(s) - anosmia , saline , platelet rich plasma , medicine , group b , platelet , endocrinology , disease , covid-19 , infectious disease (medical specialty)
Objective In this study, we aimed to functionally and morphologically demonstrate the effectiveness of platelet‐rich plasma (PRP) on anosmia in a mouse model of anosmia. Study Design Animal study. Methods A total of 16 male mice were included. When selecting the mice, the food‐finding test (FFT) was used to make sure that the animals could smell, and anosmia was induced by administration of intraperitoneal 3‐methylindole. The mice were randomly divided into two groups of eight (groups A and B). After 1 week, topical PRP was administered to the mice in group A and topical saline was administered to the mice in group B. The FFT was again administered at 7, 14, and 21 days. The mice were sacrificed on day 21, the olfactory neuroepithelium was histopathologically examined, and the epithelial damage scores and epithelial thickness were measured. Results After topical administration of PRP and saline, the difference in the average FFT values of the groups was statistically significant at 7, 14, and 21 days ( P < 0,005). During the histopathological examination, the epithelial damage score was statistically significantly lower in the PRP group ( P = 0.001) than in the saline group, and epithelial thickness was statistically significantly greater in the PRP group compared to the saline group ( P = 0.003). Conclusion We showed that PRP administration has a curative effect on olfactory functions in an anosmia‐induced mice model. However, there is a need for further research before PRP can be considered for use in patients with anosmia in clinical practice. Level of Evidence NA. Laryngoscope , 128:E157–E162, 2018