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Oral sensory dysfunction following radiotherapy
Author(s) -
Bearelly Shethal,
Wang Steven J.,
Cheung Steven W.
Publication year - 2017
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.26591
Subject(s) - medicine , cohort , tongue , soft palate , sensation , sensory system , sensory threshold , cohort study , radiation therapy , surgery , pathology , psychology , neuroscience , cognitive psychology , biology , cognitive science
Objectives/Hypothesis To assess differences in oral tactile sensation between subjects who have undergone radiation therapy (XRT) compared to healthy controls. Study Design Cross‐sectional cohort comparison. Methods Thirty‐four subjects with a history of XRT were compared with 23 healthy controls. There was no difference in age ( P = .23), but there were slightly more males in the XRT cohort ( P = .03). The mean (standard deviation) time after XRT completion was 3.84 (4.84) years. Fifty‐six percent of the XRT cohort received chemotherapy. Using our previously validated methodology to measure oral tactile sensory threshold quantitatively with Cheung‐Bearelly monofilaments, sensory thresholds of four subsites (anterior tongue, buccal mucosa, posterior tongue, soft palate) were compared for the two cohorts. Results Site‐by‐site comparisons showed higher forces were required for stimulus detection at all four subsites among subjects in the XRT cohort compared to healthy controls. Mean force in grams for XRT versus control cohorts were: anterior tongue, 0.39 (1.0) versus 0.02 (0.01); buccal mucosa, 0.42 (0.95) versus 0.06 (0.05); posterior tongue, 0.76 (1.46) versus 0.10 (0.07); and soft palate, 0.86 (1.47) versus 0.08 (0.05) ( P < .001 for all comparisons). Combining all four subsites into a single metric to assess an overall level of oral tactile dysfunction, the XRT cohort had reduced sensation by 18.7 dB ( P < .001). Conclusions After radiation therapy, the oral cavity and oropharynx exhibit global tactile sensory dysfunction, manifested by increased tactile forces required for stimulus detection. The magnitude of sensory impairment is 18.7 dB. Level of Evidence 3b. Laryngoscope , 127:2282–2286, 2017