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Long‐term local control rates of patients with adenoid cystic carcinoma of the head and neck managed by surgery and postoperative radiation
Author(s) -
Ali Safina,
Palmer Frank L.,
Katabi Nora,
Lee Nancy,
Shah Jatin P.,
Patel Snehal G.,
Ganly Ian
Publication year - 2017
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.26565
Subject(s) - medicine , adenoid cystic carcinoma , surgery , perineural invasion , port (circuit theory) , stage (stratigraphy) , retrospective cohort study , radiation therapy , salivary gland cancer , cohort , pathological , head and neck cancer , cancer , carcinoma , paleontology , electrical engineering , biology , engineering
Objectives To report long‐term local control in patients with adenoid cystic cancer (ACC) of the head and neck managed by surgery and identify factors predictive for local failure. Study Design Single‐institution retrospective cohort study. Methods Eighty‐seven patients who had surgery for ACC between 1985 and 2009 were identified. Patient, tumor, and treatment characteristics were recorded. Local recurrence‐free survival (LRFS) was recorded by the Kaplan‐Meier method. Predictors of local control were identified. Results The median age was 54 years. Seventy‐two (83%) patients had perineural invasion, 61 (70%) had close/positive margins, and 58 (67%) had pT 1T2. Fifty‐nine (68%) patients had postoperative radiation therapy (PORT). With a median follow‐up of 85 months, the 10‐year LRFS was 78.7%. There were 14 local recurrences. On multivariable analysis, pathological tumor (T)3T4 stage and no PORT were independent predictors for local failure. Patients with no PORT had a 13‐fold increased risk of local failure compared to patients treated with PORT ( P = 0.003) after adjusting for stage. Conclusion After adjusting for T stage, patients who do not get PORT are more likely to have local recurrence. Level of Evidence 4. Laryngoscope , 127:2265–2269, 2017