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Laboratory assessment of sudden sensorineural hearing loss: A case‐control study
Author(s) -
Fasano Tommaso,
Pertinhez Thelma A.,
Tribi Lorenzo,
Lasagni Daniela,
Pilia Annalisa,
Vecchia Luigi,
Baricchi Roberto,
Bianchin Giovanni
Publication year - 2017
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.26514
Subject(s) - medicine , etiology , concordance , glycated hemoglobin , guideline , disease , uric acid , diabetes mellitus , pediatrics , pathology , endocrinology , type 2 diabetes
Objectives/Hypothesis Sudden sensorineural hearing loss (SSHL) is an otologic emergency that affects five to 30 subjects per 100,000/year. The cause of SSHL remains unknown or uncertain in 70% to 90% of cases, and treatment decisions are usually made without knowing the etiology. Study Design Prospective case‐control study. Methods One hundred thirty‐one idiopathic SSHL patients were recruited from January 2014 to June 2015 in concordance with the Statements of Clinical Practice Guideline and divided into groups according to the disease severity. A clinical laboratory assessment was completed on blood samples collected from SSHL patients and control subjects. Multivariable regression analysis was performed to investigate the association between laboratory data and SSHL basis. Results Only a few SSHL patients were positive for autoimmunity or viral infection. Statistically significant ( P < .05) higher levels of blood glucose, glycated hemoglobin (HbA1C), lipoprotein (a), and factor VIII were found in SSHL patients compared to controls. Furthermore, blood glucose, HbA1C, uric acid, factor VIII, and homocysteine were significantly associated to disease severity. Conclusions Gluco‐metabolic, lipidic, and coagulative laboratory data support the vascular hypothesis for SSHL and its severity. Level of Evidence 3b Laryngoscope , 127:2375–2381, 2017