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The use of injectable calcium hydroxylapatite in the surgically pretreated larynx with glottal insufficiency
Author(s) -
Caffier Philipp P.,
I. Nasr Ahmed,
Weikert Sebastian,
Rummich Julius,
Gross Manfred,
Nawka Tadeus
Publication year - 2017
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.26261
Subject(s) - medicine , larynx , glottis , surgery , phonation , laryngoscopy , intubation , audiology
Objectives/Hypothesis To evaluate the efficacy of vocal fold (VF) augmentation with calcium hydroxylapatite (CaHA) microspheres in the surgically pretreated larynx with glottal insufficiency. Study Design Prospective clinical pilot study. Methods After several prior reconstructive attempts (following tumor resection, VF paralysis, in sulcus vocalis, and VF scarring), CaHA was injected under general anaesthesia using a transoral microlaryngoscopic approach in 10 patients with residual glottal insufficiency ≤1.5 mm. The postinterventional result was assessed after 1 day, and 1 and 3 months. Evaluation of augmentation comprised intraoperative video/photo documentation, pre‐/postoperative videolaryngostroboscopy, as well as established subjective and objective voice function diagnostics (Grade, Roughness, Breathiness [GRB] Scale; Voice Handicap Index; voice range profile; and acoustic‐aerodynamic analysis). Results In the pretreated VF with no or minimal lamina propria remaining, the exact placement of CaHA was not possible due to unpredictable propagation into the scarred tissue. The results showed an insufficient postoperative augmentation. Accordingly, the voice function did not improve. However, a significant increase of the vocal range from 6.2 ± 3.2 to 8.7 ± 3.9 semitones was observed in the speaking voice profile ( P =.02). All other acoustic and aerodynamic parameters remained on the whole unchanged; the slight differences between pre‐ and postoperative findings were not significant. Conclusions The application of CaHA in the surgically pretreated scarred larynx is not reliable to achieve a sufficient glottal closure and a satisfactory improvement of voice. Though CaHA is a welcome addition to our armamentarium against glottal insufficiency, the suitability for augmentation of scar tissue in the larynx must be considered carefully in each individual case. Level of Evidence 4 Laryngoscope , 127:1125–1130, 2017