Premium
Laryngeal chondrosarcoma: A systematic review of 592 cases
Author(s) -
Chin Oliver Y.,
Dubal Pariket M.,
Sheikh Ahmed B.,
Unsal Aykut A.,
Park Richard Chan Woo,
Baredes Soly,
Eloy Jean Anderson
Publication year - 2017
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.26068
Subject(s) - medicine , laryngectomy , epiglottis , larynx , thyroid cartilage , chondrosarcoma , cricoid cartilage , surgery , radiation therapy , laryngeal neoplasm
Objectives/Hypothesis Laryngeal chondrosarcomas are rare entities that arise from the cartilaginous structures of the larynx, including the cricoid, thyroid cartilage, epiglottis, and arytenoid cartilages. These tumors represent a minority of malignancies involving the larynx and can be mistaken for benign pathologies. The treatment has historically been surgical excision, often by total laryngectomy. This review investigates treatment modalities and patient outcomes. Study Design Systematic review using PubMed/MEDLINE and EMBASE database. Methods The databases were used to identify articles reporting cases of chondrosarcomas occurring exclusively in the larynx. Variables analyzed included patient demographics, presenting symptoms, grade, therapeutic approach, patient outcomes, and follow‐up. Results Five hundred and ninety‐two cases were identified. The average age reported was 62.5 years. There was a 3:1 male to female ratio. The most common surgical approach was local excision in 178 cases, followed by total laryngectomy in 174 cases. Nonsurgical treatment such as radiotherapy and chemotherapy was only used in 0.8% and 0.2%, respectively. Disease‐specific survival rates for 1, 5, 10, and 20 years were 97.7%, 91.4%, 81.8%, and 68.0%, respectively, with no differences when comparing 5‐year survival rates for location, grade, and therapy. Conclusion Laryngeal chondrosarcomas are rare with a good prognosis. Various surgical approaches exist, with no difference noted in 5‐year survival outcomes. Nonsurgical approaches were rarely used for these lesions. Level of Evidence N/A. Laryngoscope , 2016 127:430–439, 2017