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Laryngeal adenocarcinoma not otherwise specified: A population‐based perspective
Author(s) -
Spinazzi Eleonora F.,
Abboud Mohammad T.,
Dubal Pariket M.,
Verma Sunil P.,
Park Richard Chan Woo,
Baredes Soly,
Eloy Jean Anderson
Publication year - 2017
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.26055
Subject(s) - medicine , malignancy , incidence (geometry) , epidemiology , adenocarcinoma , population , larynx , stage (stratigraphy) , not otherwise specified , surveillance, epidemiology, and end results , cancer , retrospective cohort study , oncology , pathology , surgery , cancer registry , biology , paleontology , physics , environmental health , optics
Objectives/Hypothesis Laryngeal adenocarcinoma not otherwise specified (LAdC NOS) is a category to which variants of minor salivary gland tumors of the larynx that do not fit other well‐characterized histological subtypes are assigned. Its rare nature and inconsistency in available reports has hindered the investigation and further understanding of this malignancy. In this study, a national population‐based resource was used to evaluate the epidemiology and survival of this rare entity. Study Design Retrospective population‐based analysis. Methods The Surveillance, Epidemiology, and End Results database was searched for patients diagnosed with LAdC NOS between 1973 and 2012. Patient demographics, tumor location, TNM stage, grade, incidence, and survival trends were collected and analyzed. Results One hundred eleven patients met criteria for diagnosis of LAdC NOS, of which the majority were male (80.2%), white (84.7%), with a mean age of 65 years. The supraglottis was the most common site at presentation (38.7%). The majority presented with grade II tumor (45.7%). TNM staging revealed T2 (36.8%), N0 (72.2%), and M0 (88.9%) to be the most common classification. The overall incidence between the years of 2000 and 2012 was 0.008/100,000 individuals. The overall 5‐year disease‐specific survival (DSS) was 60.1%, compared to 85.7% in patients treated with combination surgery and radiotherapy. Conclusions LAdC NOS is an uncommon malignancy. It most commonly affects men in their mid‐60s, indiscriminate of race. Lesions most commonly present in the supraglottis and are more often low grade histologically. DSS is highest in patient treated with combination surgery and radiotherapy. Level of Evidence 4 Laryngoscope , 2016 127:424–429, 2017