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A validated method of labial minor salivary gland biopsy for the diagnosis of Sjögren's syndrome
Author(s) -
Kim Jean,
Sun Daniel,
Ozl Rebecca,
Graderbeck Thomas,
Birnbaum Julius,
Akpek Esen K.,
Baer Alan N.
Publication year - 2016
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.25974
Subject(s) - medicine , biopsy , prospective cohort study , cohort , salivary gland , dry mouth , surgery , cohort study , floor of mouth , dermatology , pathology , saliva , tongue
Objectives/Hypothesis To validate a technique and outcomes of labial minor salivary gland biopsy (LSGB) used for the diagnosis of Sjögren's syndrome (SS). Study Design Prospective cohort study. Methods Clinical data were prospectively obtained pre‐ and postbiopsy using patient‐reported questionnaires. LSGB was performed using described methods. Specimens were analyzed by a pathologist with expertise in SS and assessed using established criteria to determine the focus score. Data were analyzed using cross‐tabulations. Results Among the 58 patients in the study, 52 (90%) presented with sicca symptoms of dry eyes and/or mouth. Eight patients (14%) had histopathologic findings supportive of a diagnosis of SS. At 1 month postbiopsy, greater than 71% of patients denied any complaints of pain, swelling, numbness. or tingling. Sixteen patients (28%) had only a minor level of complaints. Only one patient complained of severe numbness at the biopsy site. Greater than 70% of patients would consider rebiopsy after the procedure, if requested by their physician. Conclusions We present a safe and effective method of LSGB for the diagnosis of SS. Level of Evidence 4 Laryngoscope , 126:2041–2046, 2016