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Asbestos exposure and laryngeal cancer mortality
Author(s) -
Peng Wenjia,
Mi Jing,
Jiang Yuhong
Publication year - 2016
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1002/lary.25693
Subject(s) - asbestos , medicine , lung cancer , mesothelioma , confidence interval , cancer , meta analysis , asbestosis , environmental health , standardized mortality ratio , oncology , pathology , lung , materials science , metallurgy
Objectives/Hypothesis Occupational exposure to asbestos occurs in many workplaces and is well known to cause asbestosis, lung cancer, and mesothelioma. However, the link between asbestos exposure and other malignancies was not confirmed. The aim of the current meta‐analysis was to provide a summary measure of risk for laryngeal cancer associated with occupational asbestos exposure. Study Design Systematic review and meta‐analysis. Methods Electronic databases were searched for studies characterizing the association between asbestos and laryngeal cancer. Standardized mortality rate (SMR) with its 95% confidence interval (CI) of each study was combined using a fixed or random effect model. Results Significantly increased SMR for laryngeal cancer was observed when subjects were exposed to asbestos (SMR = 1.69, 95% CI = 1.45‐1.97, P < .001), with little evidence of heterogeneity among studies ( Q = 15.39, P = .803, I 2 = 0.0%). Effect estimates were larger for cohorts controlling for male subjects, Europe and Oceania, mining and textile industries, exposure to crocidolite, long study follow‐up (>25 years), and SMR for lung cancer > 2.0. Publication bias was not detect by Begg test ( P = .910) and Egger test ( P = .340). Conclusions Our study supports the association of exposure to asbestos with an increased risk of laryngeal cancer mortality among male workers. Level of Evidence NA Laryngoscope , 126:1169–1174, 2016